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Kidney function in rats with corticomedullary nephrocalcinosis: effects of alterations in dietary calcium and magnesium.
Author(s) -
Al-Modhefer A K,
Atherton J C,
Garland H O,
Singh H J,
Walker J
Publication year - 1986
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1986.sp016293
Subject(s) - nephrocalcinosis , calcium , magnesium , kidney , endocrinology , medicine , renal function , magnesium deficiency (plants) , chemistry , organic chemistry
Single‐nephron and whole‐kidney function were studied in female rats with corticomedullary nephrocalcinosis, and in animals where the lesion had been prevented either by a dietary magnesium supplement or by using a diet with a calcium:phosphorus ratio in excess of 1. At the single‐nephron level, rats with nephrocalcinosis had prolonged tubular fluid transit times. Proximal transit time was 19.42 +/‐ 1.98 (mean +/‐ S.E. of mean) vs. 11.58 +/‐ 0.19 s for controls; distal transit time was 62.64 +/‐ 9.16 vs. 31.50 +/‐ 1.03 s for controls. Although single‐nephron function is altered in nephrocalcinosis, data obtained from rats in metabolism cages indicate that whole‐kidney function is largely unaffected by the lesion.

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