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Renal vasoconstrictor response to hypertonic saline in the dog: effects of prostaglandins, indomethacin and theophylline.
Author(s) -
Gerber J G,
Nies A S
Publication year - 1986
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1986.sp016270
Subject(s) - hypertonic saline , theophylline , saline , tonicity , chemistry , medicine , endocrinology , prostaglandin , renovascular hypertension , kidney
The role of prostaglandins in the mechanism of the tubuloglomerular feed‐back was examined in the anaesthetized dog using the infusion of hypertonic saline to increase renal plasma sodium concentration by 30 mmol/l as the stimulus to activate the tubuloglomerular feed‐back. Two sequential infusions of hypertonic saline into the renal artery for 10 min separated by 90 min resulted in equivalent reductions in renal blood flow (264 +/‐ 32 to 174 +/‐ 20 ml/min first time; 280 +/‐ 29 to 200 +/‐ 15 ml/min second time). Administration of indomethacin, 8 mg/kg, between the two infusions did not alter the renovascular response to hypertonic saline (319 +/‐ 26 to 226 +/‐ 35 ml/min vs. 288 +/‐ 32 to 202 +/‐ 24 ml/min). Infusion of either prostaglandin E2 (PGE2) or prostaglandin I2 (PGI2) during the second hypertonic saline infusion period also resulted in no change in the renovascular response (251 +/‐ 37 to 141 +/‐ 31 ml/min vs. 297 +/‐ 53 to 184 +/‐ 51 ml/min; and 223 +/‐ 31 to 162 +/‐ 35 ml/min vs. 254 +/‐ 33 to 186 +/‐ 39 ml/min, respectively). Intrarenal theophylline, to a concentration of 40 micrograms/ml, however, totally abolished the renovascular response to hypertonic saline (279 +/‐ 20 to 209 +/‐ 13 ml/min control vs. 390 +/‐ 26 to 402 +/‐ 17 ml/min during theophylline). The systemic hypertensive response during the infusion of hypertonic saline was unaltered by indomethacin or prostaglandins but was totally abolished by theophylline.(ABSTRACT TRUNCATED AT 250 WORDS)