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The subtype of alpha‐adrenoceptor involved in the neural control of renal tubular sodium reabsorption in the rabbit.
Author(s) -
Hesse I F,
Johns E J
Publication year - 1984
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1984.sp015308
Subject(s) - renal blood flow , renal sodium reabsorption , endocrinology , medicine , renal physiology , chemistry , kidney , stimulation , reabsorption , renal function , yohimbine , renal circulation , diuresis , natriuresis , effective renal plasma flow , sodium , urine flow rate , receptor , antagonist , organic chemistry
A study was undertaken in pentobarbitone anaesthetized rabbits, undergoing a saline diuresis, to determine the subtype of alpha‐adrenoceptor mediating renal tubular sodium reabsorption. Stimulation of the renal nerves at low rates, to cause an 11% fall in renal blood flow, did not change glomerular filtration rate but significantly reduced urine flow rate, and absolute and fractional sodium excretions by approximately 40%. These responses were reproducible in different groups of animals and with time. Renal nerve stimulation during an intra‐renal arterial infusion of prazosin, to block alpha 1‐adrenoceptors, had no effect on the renal haemodynamic response but completely abolished the reductions in urine flow rate, and absolute and fractional sodium excretion. During intra‐renal arterial infusion of yohimbine, to block renal alpha 2‐adrenoceptors, stimulation of the renal nerves to cause similar renal haemodynamic changes resulted in significantly larger reductions in urine flow rate, and absolute and fractional sodium excretion of about 52‐58%. These results indicate that in the rabbit alpha 1‐adrenoceptors are present on the renal tubules, which mediate the increase in sodium reabsorption caused by renal nerve stimulation. They further suggest the presence of presynaptic alpha 2‐adrenoceptors on those nerves innervating the renal tubules.