Premium
Characteristics of the neuroendocrine responses to stimulation of the splanchnic nerves in bursts in the conscious calf.
Author(s) -
Bloom S R,
Edwards A V
Publication year - 1984
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1984.sp015039
Subject(s) - phentolamine , splanchnic nerves , propranolol , endocrinology , hexamethonium , stimulation , medicine , splanchnic , glucagon , atropine , insulin , blockade , pancreatic polypeptide , cholinergic , blood flow , receptor
Neuroendocrine responses to splanchnic nerve stimulation in bursts (at 40 Hz for 1 s at 10 s intervals for 10 min) have been investigated in conscious adrenalectomized calves, 3‐6 weeks after birth, in the presence of various pharmacological blocking agents. Preganglionic blockade with hexamethonium abolished all the neuroendocrine responses that were monitored. Pre‐treatment with phentolamine significantly reduced, but failed to eliminate, the release of both pancreatic glucagon and pancreatic polypeptide. In the presence of phentolamine splanchnic nerve stimulation produced a massive rise in arterial plasma insulin concentration. None of these pancreatic neuroendocrine responses was significantly affected by additional pre‐treatment with propranolol. The rise in mean plasma insulin concentration which occurred in calves pre‐treated with both phentolamine and propranolol was significantly reduced by atropine. Release of bombesin‐like immunoreactivity (BLI) was unaffected by total post‐ganglionic adrenergic and cholinergic blockade. The results indicate that pancreatic endocrine responses to splanchnic nerve stimulation may be attributable, at least in part, to release of BLI in this species.