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Effects of vasoactive intestinal polypeptide (VIP) on renal function and plasma renin activity in the conscious rabbit.
Author(s) -
Dimaline R,
Peart W S,
Unwin R J
Publication year - 1983
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1983.sp014946
Subject(s) - vasoactive intestinal peptide , plasma renin activity , endocrinology , medicine , chemistry , filtration fraction , renin–angiotensin system , renal blood flow , renal function , renal physiology , effective renal plasma flow , sodium , hemodynamics , kidney , blood pressure , neuropeptide , receptor , organic chemistry
Conscious rabbits received either vasoactive intestinal polypeptide (VIP) at a dose of 1, 10 or 25 pmol kg‐1 min‐1 or vehicle alone (control) through an ear vein for 2 h. Experimental design followed a randomized Latin square arrangement. VIP led to a decrease in effective renal plasma flow and glomerular filtration rate (P less than 0.01) during infusion of the middle and high doses. Mean arterial blood pressure rose slightly (P less than 0.05) and filtration fraction increased (P less than 0.01) during infusion of the middle dose. The high dose produced a rise in heart rate, a fall in plasma sodium, potassium and phosphate concentrations and a rise in plasma solids (P less than 0.01). In spite of the renal haemodynamic effects and changes in plasma composition during infusion of the high dose, fractional excretion of sodium, potassium and chloride doubled (P less than 0.05), suggesting a direct action of VIP on renal tubular function. Plasma renin activity increased between 2‐ and 3‐fold (P less than 0.01). The mechanism of the renin response is uncertain. These results, together with the reported presence of VIP‐like material in the renal cortex, may indicate a role for VIP in the regulation of renal function, including renin release.