Sodium and chloride co‐transport by preimplantation rabbit blastocysts. | Zendy

Benos D J | Zendy; Biggers J D | Zendy

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Sodium and chloride co‐transport by preimplantation rabbit blastocysts.

Author(s) -

Benos D J,

Biggers J D

Publication year - 1983

Publication title -

the journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.802

H-Index - 240

eISSN - 1469-7793

pISSN - 0022-3751

DOI - 10.1113/jphysiol.1983.sp014837

Subject(s) - blastocyst , ouabain , chemistry , furosemide , sodium , medicine , endocrinology , embryo , chloride , transport system , andrology , biology , embryogenesis , microbiology and biotechnology , organic chemistry , transport engineering , engineering

Influxes of Na+ and Cl‐ across the trophectodermal epithelium of 6 day post coitum (p.c.) rabbit blastocysts are partially interrelated. This relationship was investigated under conditions in which either the external [Na+] or [Cl‐] concentration was varied. Our results indicate that an ouabain‐insensitive, furosemide‐sensitive, Na+:Cl‐ co‐transport system exists in the 6 and 6.5 day p.c. rabbit embryo, but not in the 5 day p.c. blastocyst. There was no dependence of NaCl uptake on the presence of K+ in the bathing medium. No evidence of Na+/H+ or Cl‐/HCO3‐ exchange systems in the rabbit blastocyst was found. The effects of furosemide, exogenous cyclic AMP, and various exogenous prostaglandins on Na+ and Cl‐ movements were studied. Cyclic AMP and/or prostaglandin E1 may regulate the operation of this Na+:Cl‐ co‐transport system.

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