The influence of pH on the healing‐over of mammalian cardiac muscle. | Zendy

De Mello W C | Zendy

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The influence of pH on the healing‐over of mammalian cardiac muscle.

Author(s) -

De Mello W C

Publication year - 1983

Publication title -

the journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.802

H-Index - 240

eISSN - 1469-7793

pISSN - 0022-3751

DOI - 10.1113/jphysiol.1983.sp014717

Subject(s) - ventricle , intracellular , extracellular , biophysics , membrane , chemistry , cardiac muscle , anatomy , biology , medicine , cardiology , biochemistry

The process of healing‐over was followed in trabeculae from the right ventricle of guinea‐pigs and in Purkinje fibres from dogs by measuring resting potential and input resistance close to a site of damage. In Ca2+‐free bathing solution at pH 6.5 no signs of healing‐over were found; at pH 5.5 healing‐over was incomplete; at pH 5.0 and 4.0 healing‐over occurred promptly. It is concluded that transformation of low‐resistance nexus membranes into high‐resistance membranes separating the intracellular from the extracellular compartment normally is due to Ca2+, while protons can bring about the same effect under extreme conditions.

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