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Plasma vasopressin concentration in the anaesthetized dog before, during and after atrial distension.
Author(s) -
Ledsome J R,
Ngsee J,
Wilson N
Publication year - 1983
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1983.sp014680
Subject(s) - distension , chloralose , vasopressin , medicine , endocrinology , radioimmunoassay , plasma osmolality , plasma concentration , chemistry , anesthesia , blood pressure
Plasma vasopressin (AVP) concentration in dogs anaesthetized with chloralose was measured by radioimmunoassay and was within the range of 2‐5 pg/ml. during control periods. Distension of the left atrium led within 2 min to a fall in plasma AVP concentration which reached a steady lower value within 4 min. After cessation of atrial distension the AVP concentration returned to pre‐distention values within 4 min. Cooling the cervical vagosympathetic nerves to 8‐10 degrees C led to a rise in plasma AVP concentration. Atrial distension during cooling of the vagi resulted in a further increase of plasma AVP concentration.