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Effect of stimulation or lesioning of the hypothalamus upon gonadotrophin secretion in the guinea‐pig.
Author(s) -
Donovan B T,
Gnanathankom M G
Publication year - 1983
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1983.sp014609
Subject(s) - hypothalamus , endocrinology , estrous cycle , medicine , stimulation , follicular phase , luteinizing hormone , guinea pig , luteal phase , secretion , follicle stimulating hormone , hormone , biology , chemistry
The effect of electrical stimulation of the anterior hypothalamus of the guinea‐pig upon follicle‐stimulating hormone (FSH) and luteinizing hormone (LH) secretion during two phases of the oestrous cycle was examined and compared with the response to electrolytic or radio‐frequency lesions placed in the same area. The secretion of LH was briefly increased by electrical stimulation of the hypothalamus, with a greater response occurring over days 7‐8 (luteal phase) of the oestrous cycle than on days 13‐14 (follicular phase). An equivalent rise in LH output was produced by placement of direct current (d.c.) lesions in the hypothalamus, whereas lesions made with radio‐frequency current produced a small increase only on days 13‐14. The secretion of FSH was not changed by any procedure.