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Effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall‐bladder to cholecystokinin.
Author(s) -
Johnson A G,
Marshall C E,
Wilson I A
Publication year - 1982
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1982.sp014421
Subject(s) - cholecystokinin , secretin , somatostatin , medicine , endocrinology , pentagastrin , hormone , gastrin , motilin , chemistry , gastrointestinal hormone , atropine , peptide hormone , peptide , propranolol , pancreas , stomach , secretion , biochemistry , receptor , gastric acid
1. The efficacies of some standard preparations of CCK were compared and the effects of some drugs and peptide hormones on the responsiveness of the rabbit isolated gall‐bladder to cholecystokinin were studied with an established automatic method of estimating cholecystokinin. 2. Atropine, propranolol, phentolamine mesylate and lignocaine were shown to have no effect on the responsiveness of the rabbit isolated gall‐bladder. 3. Glucagon, somatostatin, pentagastrin, pancreatic polypeptide, motilin and the Karolinska preparation of secretin had no effect on the preparation alone and caused only slight changes when given with cholecystokinin. 4. The Boots preparation of secretin exhibited a small cholecystokinin effect when given alone, but considerably inhibited cholecystokinin‐induced contractions. 5. The desulphated C‐terminal octapeptide of cholecystokinin also exhibited inhibitory effects.