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Pressure‐volume relationships above and below atmospheric pressure in the synovial cavity of the rabbit knee.
Author(s) -
Knight A D,
Levick J R
Publication year - 1982
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1982.sp014273
Subject(s) - volume (thermodynamics) , chemistry , atmospheric pressure , saline , sigmoid function , anatomy , thermodynamics , anesthesia , medicine , physics , meteorology , machine learning , artificial neural network , computer science
1. The pressure‐volume relationship in the synovial cavity of the rabbit knee was investigated by the infusion of a non‐absorbable oil into the cavity. 2. The pressure (P)‐volume (V) curve was sigmoid. Its slope dP/dV (elastance) was steep at subatmospheric, physiological pressures, least steep at 5 cm H2O, and steepened progressively at higher, pathological pressures. 3. Elastance dP/dV was a good approximation to linear functions of P below atmospheric pressure and above 5 cm H2O. Each part of the pressure‐volume relationship could therefore be described by an exponential expression. 4. Flexion of the joint increased pressure at a given volume. This was mainly due to steepening of the pressure‐volume curve, and also partly due to a shift towards the pressure axis. 5. Pressure‐volume curves determined by the infusion of normal saline or Krebs solution were grossly distorted, because these fluids were absorbed across the permeable synovium. 6. The physiological significance of the synovial pressure‐volume curve is discussed, and mechanical explanations of the curve are suggested.