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The effects of alanine, glucose and starch ingestion on the ketosis produced by exercise and by starvation.
Author(s) -
Koeslag J H,
Noakes T D,
Sloan A W
Publication year - 1982
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1982.sp014155
Subject(s) - ketosis , endocrinology , medicine , ketone bodies , starvation , ingestion , ketoacidosis , carbohydrate , glucagon , chemistry , insulin , alanine , starch , diabetes mellitus , biochemistry , metabolism , type 1 diabetes , amino acid
1. Several investigators have found that the development of post‐exercise ketosis is not counteracted by glucose ingestion. Post‐exercise ketosis might therefore have more in common with diabetic ketoacidosis than with starvation ketosis. 2. The effects of ingesting 100 g of glucose, alanine or starch were therefore studied in subjects rendered hyperketonaemic by prolonged running on a low carbohydrate diet, or by 65 h of starvation. These substances were also ingested by normal post‐prandial subjects. 3. The runners developed post‐exercise ketosis (1.81 +/‐ S.D. 0.81 mmol/l), which was counteracted by alanine and glucose, but only minimally by starch. 4. Fasting caused a variable ketosis (2.19 +/‐ S.D. 1.63 mmol/l), also counteracted by glucose and less by starch, but alanine caused vomiting. 5. Glucose and alanine lowered the blood ketone body levels of the post‐prandial subjects. 6. The rising ketone body levels in starvation and after exercise were accompanied by simultaneous increases in the plasma insulin/glucagon ratios; in both, glucose ingestion increased the ratio further, while alanine decreased it. 7. It is concluded that there is no essential difference between established post‐exercise and starvation ketosis, and that the blood fuel‐hormone changes do not correlate with the changes in blood ketone body concentrations.