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Inhibition, by trichothecene antibiotics, of brain protein synthesis and fever in rabbits.
Author(s) -
Can M,
Cranston W I,
Hellon R F,
Townsend Y
Publication year - 1982
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1982.sp014048
Subject(s) - trichothecene , antibiotics , microbiology and biotechnology , pharmacology , biology , chemistry , medicine , virology , toxin
1. To test further the hypothesis that brain protein synthesis is necessary for fever, three structurally similar trichothecene antibiotics were injected into the cerebral ventricles of rabbits. They were 3,15‐diacetoxy‐12‐hydroxytrichothec‐9‐ene (DAHT), 3,15‐didesacetyl‐calonectrin (DDAC) and T‐2 toxin. Their actions on hypothalamic incorporation of [14C]leucine and fever were compared. 2. DDAC (60 micrograms) and T‐2 toxin (10 micrograms) strongly inhibited leucine incorporation and fever. DAHT (60 micrograms) did not diminish fever and had a smaller effect upon leucine incorporation. 3. The findings strengthen considerably earlier suggestions that brain protein synthesis is an essential step in pyrogenesis.