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Pancreatic endocrine responses to exogenous neurotensin in the conscious calf.
Author(s) -
Blackburn A M,
Bloom S R,
Edwards A V
Publication year - 1981
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1981.sp013686
Subject(s) - neurotensin , endocrinology , medicine , glucagon , pancreatic polypeptide , endocrine system , insulin , peptide hormone , chemistry , hormone , neuropeptide , receptor
1. Responses to neurotensin have been investigated in conscious calves 2‐5 weeks after birth given continuous I.V. infusions of the peptide for 15 min (5 pmol. kg‐1 . min‐1). 2. In control calves the concentration of the peptide in the arterial plasma had risen by 160 +/‐ 10 pmol/l at the end of the infusion,. after which it fell exponentially (t1/2: 1.4 min). 3. This dose of neurotensin produced no significant change in mean heart rate, aortic blood pressure, plasma gastrin or glucose concentration. 4. It was found that neurotensin could produce a pronounced rise in the concentration of both insulin and pancreatic polypeptide (PP) in the arterial plasma, together with a much smaller rise in pancreatic glucagon concentration. 5. Each of these three pancreatic endocrine responses was found to be glucose‐sensitive within the range ca. 5.0‐9.0 mmol/l. Hyperglycaemia potentiated insulin release and inhibited release of PP and glucagon. 6. The results are discussed in relation to the findings of other workers in other species.