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Sensitization in voltage clamped barnacle photoreceptors.
Author(s) -
Bolsover S R
Publication year - 1980
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1980.sp013386
Subject(s) - sensitization , depolarization , biophysics , prepulse inhibition , chemistry , desensitization (medicine) , membrane potential , neuroscience , medicine , biology , biochemistry , schizophrenia (object oriented programming) , receptor , psychiatry
1. The light response of Balanus lateral eye photoreceptor was studied using intracellular recording and voltage clamp techniques. 2. The effect upon the light response of a prior depolarization was studied. Two effects were observed: a transient sensitization which appeared not to involve a change in time course, and a long‐lived desensitization which was accompanied by a reduction in response time course. 3., The sensitizing effect of depolarizing prepulses increased monotonically with prepulse duration; it was maximal for pulses to around +20 mV. 4. Sensitization was inhibited by perfusion with salines containing cobaltous ions or with calcium‐free saline. 5. It is concluded that while desensitization is an effect upon the transduction mechanism, sensitization is a direct influence of a prior depolarization on the light‐activated channels.