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The mechanism of drinking induced by parenteral hyperoncotic solutions in the pigeon and in the rat
Author(s) -
Kaufman Susan,
Kaesermann HansPeter,
Peters Georges
Publication year - 1980
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1980.sp013191
Subject(s) - polyethylene glycol , polyethylene , chemistry , diuresis , polyvinyl alcohol , peg ratio , zoology , biochemistry , renal function , organic chemistry , biology , finance , economics
1. In pigeons, the I.V. injection of 0·3‐1·3 ml. of 50% (w/w) solutions of either polyethylene glycol (mol.wt. 20,000) or dextran (mol.wt. 40,000) induced reliable, rapid dose‐dependent drinking responses. The amount of water drunk in response to I.V. polyethylene glycol was greater than that in response to I.P. polyethylene glycol and twice that in response to I.V. dextran. I.V. polyethylene glycol induced a diuresis following the onset of drinking. 2. The dipsogenic effect of I.P. polyethylene glycol solutions in the pigeon was depressed by I.V. isotonic NaCl solution 1 hr before offering water but was increased by simultaneous I.V. hyperoncotic polyethylene glycol solution. 3. In contrast, in rats, the subcutaneous injection of 25% (w/w) polyethylene glycol (mol.wt. 20,000; 1·25‐10·0 ml./kg body wt.) induced reliable drinking responses, while the same doses of polyethylene glycol, injected I.V. , did not induce drinking consistently. The volume of water drunk by rats in response to subcutaneous polyethylene glycol was smaller per unit dose than that drunk by I.P. injected pigeons. 4. The results suggest that receptors for drinking induced by extracellular dehydration in the pigeon could be situated in the extravascular interstitial section of the extracellular compartment.