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The effcts of sodium fluoride on gastric acid and electrolyte output in the anaesthetized cat.
Author(s) -
Reed J D,
Smy J R
Publication year - 1980
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1980.sp013186
Subject(s) - histamine , chemistry , sodium , medicine , endocrinology , electrolyte , gastric acid , chloride , sodium fluoride , secretion , fluoride , biochemistry , inorganic chemistry , biology , organic chemistry , electrode
1. The possibility of a Na+/H+ exchange mechanism in the presence of NaF (Bond & Hunt, 1956) has been studied in acid secreting and non‐acid secreting stomachs of anaesthetized cats. 2. In non‐acid secreting stomachs, although H+ loss and Na+ gain were both pH related, there was no constant relationship between the two. 3. The H+ loss in non‐acid secreting stomachs could not account for the H+ loss in histamine stimulated stomachs. 4. In acid secreting stomachs the Na+ or neutral Cl‐ gain was only of the order of 50% of the H+ loss, and, in the presence of isosmolal NaNO3, NaF produced the same reduction in H+ but with a markedly suppressed gain in neutral chloride. 5. The NaF induced reduction in H+ output was accompanied by reductions in the total Cl‐ output, the K+ output and the mucosal blood flow. 6. It is concluded that the reduction in H+ output from histamine stimulated stomachs is largely a result of inhibition of secretion.