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Increased sensitivity of ADH bio‐assay in rats by change in diet.
Author(s) -
Kappagoda C T,
Linden R J,
Pashley M
Publication year - 1980
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1980.sp013134
Subject(s) - vasopressin , antidiuretic , weaning , casein , urine , zoology , biology , ethanol , chemistry , food science , endocrinology , medicine , biochemistry
1. Water‐loaded rats anaesthetized with ethanol were used for the detection of antidiuretic hormone (ADH). 2. Litter‐mates were divided into groups and placed on different diets during the fourth week of life directly after weaning, and maintained on their respective diets for approximately 1 month and their sensitivity to vasopressin was determined. 3. The rats maintained on a diet of only vegetable or vegetable plus casein supplement showed a greater sensitivity to exogenous vasopressin than rats maintained on a standard laboratory diet (pellets). 4. It is proposed that the quantitative relationship between ADH and urine flow is dependent upon the previous history of water consumption.