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Gastric secretion provoked by functional cytoglucopoenia in the nuclei of the solitary tract in the cat.
Author(s) -
Kadekaro M,
TimoIaria C,
Vicentini M de L
Publication year - 1980
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1980.sp013132
Subject(s) - microinjection , secretion , reflex , dorsal motor nucleus , stimulation , solitary tract , medicine , cats , vagus nerve , endocrinology , saline , biology , gastrointestinal tract , chemistry , inhibitory postsynaptic potential , anatomy , central nervous system
1. A rhomboencephalic reflex loop involved in the gastrosecretory effect of functional cytoglucopoenia caused by 2‐deoxy‐D‐glucose (2‐DG) was investigated in thirty‐five cats prepared with chronic gastric fistulae. 2. Injection of 60 mg 2‐DG/kg in the vertebral artery of cats subjected to acute electrolytic transection of the pontomedullary transition produced gastric secretion. 3. Microinjection of 2‐DG in the medial and in the lateral components of the nuclei of the solitary tract elicited an intense gastric secretion. Sites at the level of the obex were more effective than the caudalmost portions of the nuclei in causing the secretory effect. Microinjection of saline in the same nuclei was totally ineffective whereas both saline and 2‐DG solutions induced secretion when microinjected in the dorsal nuclei of the vagus. The gastrosecretory effect of microinjection of saline and 2‐DG in the dorsal nuclei of the vagus is ascribed to mechanical stimulation of the effector parasympathetic neurones that innervate gastric mucosa. 4. It is concluded that rhomboencephalic neurones sensitive to functional cytoglucopoenia are located in the nuclei of the solitary tract. Activation of these neurones conveys to effector neurones information that triggers gastric secretion.