Premium
Cyclic GMP and the permeability of the disks of the frog photoreceptors.
Author(s) -
Caretta A,
Cavaggioni A,
Sorbi R T
Publication year - 1979
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1979.sp012959
Subject(s) - guanosine , chemistry , sodium , biophysics , potassium , membrane , egta , rubidium , cyclic guanosine monophosphate , calcium , adenosine , ion , membrane permeability , biochemistry , biology , nitric oxide , organic chemistry
1. The diffusion of sodium, potassium and rubidium (not chloride) ions across the disk membrane is increased by cyclic guanosine monophosphate (cyclic GMP). 2. The increase is greater for sodium than for rubidium in the 0.01‐0.1 mM concentration range. 3. Cyclic adenosine monophosphate (cyclic AMP) is less efficient than cyclic GMP; GMP and guanosine triphosphate are without effect. 4. The effect is present with either 1.8 mM calcium ions or 4 mM‐EGTA in the perfusion fluid. 5. The presence of the cyclic GMP phosphodiesterase on the disk membranes is not needed for this effect. 6. The effect is present in both unbleached and fully bleached membranes.