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A voltage‐dependent gate in series with the inwardly rectifying potassium channel in frog striated muscle.
Author(s) -
Mancinelli E,
Peres A
Publication year - 1979
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1979.sp012890
Subject(s) - conductance , potassium , chemistry , biophysics , hyperpolarization (physics) , potassium channel , membrane potential , voltage clamp , extracellular , anatomy , biochemistry , biology , stereochemistry , physics , organic chemistry , nuclear magnetic resonance spectroscopy , condensed matter physics
1. The degree of tubular potassium depletion and the decrease of potassium conductance due to hyperpolarizing pulses in striated muscular fibres have been examined with the three micro‐electrode voltage‐clamp technique. 2. The conductance of the fibre membrane has been measured in different extracellular K+ concentrations from 1 to 10 mM. 3. Comparison of the two sets of measurements shows that changes in tubular K+ concentration are not sufficient to account for the conductance decrease associated with hyperpolarization. 4. The presence of a voltage‐dependent gate in series with the inwardly rectifying channel for K+ ions, suggested by Almers (1972a, b), is thus confirmed.