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Fever induced in rabbits by intravenous injection of bovine serum albumin.
Author(s) -
Hattingh J,
Laburn H,
Mitchell D
Publication year - 1979
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1979.sp012760
Subject(s) - bovine serum albumin , albumin , serum albumin , medicine , endogeny , chemistry , anesthesia , immunology
1. Bovine serum albumin injected into conscious rabbits produced a dose‐dependent fever of short latency and duration of at least 2 1/2 hr. 2. The fever was not due to contamination by other proteins nor due to contamination by bacterial endotoxin. 3. The fever following albumin injection had characteristics similar to endogenous pyrogen fever. 4. Some traditional ways of distinguishing bacterial endotoxin fever from other types of fever need to be reassessed.