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The effect of dopamine on shivering in the rat.
Author(s) -
Marshall H W,
Stoner H B
Publication year - 1979
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1979.sp012702
Subject(s) - pimozide , shivering , dopamine , apomorphine , dopamine antagonist , chemistry , antagonist , dopamine receptor , inhibitory postsynaptic potential , hypothermia , endocrinology , medicine , pharmacology , anesthesia , receptor , dopaminergic , biochemistry , haloperidol
1. Dopamine (0.5‐‐0.2 mumole) injected into a lateral cerebral ventricle inhibited shivering and lowered core temperature in rats at an ambient temperature of 0‐‐5 degrees C. 2. These effects were inhibited by the dopamine antagonist, pimozide, and imitated by the dopamine agonists, piribedil and apomorphine. 3. Pimozide itself had no effect on shivering. 4. It is concluded that while there are inhibitory dopamine receptors on the cold sensor‐‐shivering pathway in the rat they are not concerned in the normal function of this pathway.