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Effect of antrum exclusion on endocrine cells of rat stomach.
Author(s) -
Alumets J,
El Munshid H A,
Håkanson R,
Liedberg G,
Oscarson J,
Rehfeld J F,
Sundler F
Publication year - 1979
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1979.sp012610
Subject(s) - gastrin , histidine decarboxylase , histamine , g cell , antrum , enteroendocrine cell , medicine , endocrinology , enterochromaffin like cell , granule (geology) , endocrine system , gastric mucosa , regulation of gastric function , chemistry , enterochromaffin cell , pyloric antrum , biology , stomach , secretion , biochemistry , hormone , enzyme , histidine , serotonin , paleontology , receptor
1. Following antrum exclusion the serum gastrin concentration was raised and independent of the prandial state. The antral gastrin concentration and number of gastrin cells were greatly lowered. 2. The histamine content and the number of histamine‐storing endocrine ('entero‐chromaffin‐like') cells in the oxyntic mucosa was almost doubled and the mucosal histidine decarboxylase activity was greatly elevated following antrum exclusion. 3. At the ultrastructural level both types of histamine‐storing endocrine cells (ECL and A‐like) were found to be enlarged and to have a reduced number of granules per unit cytoplasm. These changes are compatible with an increased secretory activity. The G (gastrin) cells were not increased in size but their granule volume density was lowered. 4. We propose that antrum exclusion results in uninhibited gastrin release causing profound changes in the histamine‐storing endocrine cells of the oxyntic mucosa. The cells respond to the hypergastrinemia by an increase in functional activity (activation of histidine decarboxylase and reduction of granule volume density) as well as by an increase in number and size.