A transient release of potassium mediated by the action of substance P on rat parotid slices. | Zendy

Friedman Z Y | Zendy; Selinger Z | Zendy

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A transient release of potassium mediated by the action of substance P on rat parotid slices.

Author(s) -

Friedman Z Y,

Selinger Z

Publication year - 1978

Publication title -

the journal of physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.802

H-Index - 240

eISSN - 1469-7793

pISSN - 0022-3751

DOI - 10.1113/jphysiol.1978.sp012317

Subject(s) - phentolamine , substance p , atropine , endocrinology , peptide , medicine , chemistry , cholinergic , potassium , amino acid , biochemistry , biology , stimulation , neuropeptide , receptor , organic chemistry

Substance P (a peptide of eleven amino acids) caused a Ca‐dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha‐adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused little, if any, amylase secretion. Successive additions of the peptide to the slice system maintained the effect of C+ release indicating that the transient response to a single addition of the peptide was due to inactivation of substance P and not due to a decline in the response of the tissue.

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