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A transient release of potassium mediated by the action of substance P on rat parotid slices.
Author(s) -
Friedman Z Y,
Selinger Z
Publication year - 1978
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1978.sp012317
Subject(s) - phentolamine , substance p , atropine , endocrinology , peptide , medicine , chemistry , cholinergic , potassium , amino acid , biochemistry , biology , stimulation , neuropeptide , receptor , organic chemistry
Substance P (a peptide of eleven amino acids) caused a Ca‐dependent release of K+ from rat parotid slices. The response to substance P differed from the alpha‐adrenergic and the cholinergic responses in that it was transient, of smaller extent, and was not inhibited by phentolamine and atropine. Substance P caused little, if any, amylase secretion. Successive additions of the peptide to the slice system maintained the effect of C+ release indicating that the transient response to a single addition of the peptide was due to inactivation of substance P and not due to a decline in the response of the tissue.