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The effect of lung inflation on the control of respiratory frequency in the neonate
Author(s) -
Boychuk Rodney B.,
Rigatto Henrique,
Seshia Mary M. K.
Publication year - 1977
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1977.sp011973
Subject(s) - respiratory system , expiration , respiratory frequency , tidal volume , lung volumes , anesthesia , medicine , term (time) , lung , cardiology , physics , quantum mechanics
1. We have measured the relationship between tidal volume ( V T ) and the duration of inspiration ( T i ) and expiration ( T e ) for individual breaths (30 in each steady state). 2. Ten pre‐term and ten term infants were studied during steady state while breathing 21% O 2 , then 21% O 2 plus 2 and 4% CO 2 . 3. In all infants, the average T i at the various chemical drives was remarkably constant, and did not decrease as the tidal volume increased. However, at any given level of respiratory drive, there was a slightly positive correlation of V T with T i and T e in 95% of the cases. 4. In four pre‐term and two term infants, T e increased with increasing respiratory drive. In these infants, therefore, instantaneous respiratory frequency (1/( T i + T e )) actually decreased as lung volume increased. 5. We suggest that T i is independent of V T within the range of volumes studied (up to 2 times the resting V T ) and that changes in instantaneous respiratory frequency (1/( T i + T e )) result from changes in T e .