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The secretion of pepsin.
Author(s) -
Kondo T,
Magee D F
Publication year - 1977
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1977.sp011936
Subject(s) - pepsin , secretion , pentagastrin , ligation , chemistry , gastric secretion , stomach , medicine , endocrinology , gastric acid , biochemistry , enzyme
1. Ligation and division of the vessels supplying the stomach, except those from the spleen, result in greatly increased pepsin secretion in response to pentagastrin, pilocarpine or 2‐deoxy‐D‐glucose. 2. This effect was still present 6 months after initial ligation. 3. Analysis of dose‐response curves shows that for pepsin secretion the Vmax values were raised by this procedure. 4. Right‐sided vessel ligation and division does not alter acid secretion in response to the stimuli used. 5. It is suspected that the procedure of right‐sided vessel ligation removes a non‐competitive inhibitor mechanism to gastric pepsin secretion.