Premium
Quantitative assessment of cardiac pump performance.
Author(s) -
Bishop V S,
Horwitz L D
Publication year - 1977
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1977.sp011906
Subject(s) - stroke volume , cardiology , heart rate , frank–starling law of the heart , cardiac output , medicine , inotrope , stroke (engine) , volume (thermodynamics) , blood pressure , starling , anesthesia , physics , quantum mechanics , thermodynamics
1. A means of quantitating left ventricular performance in the conscious dog is presented. Changes in heart rate, stroke volume and cardiac output during elevation of left atrial pressure by acute volume expansion were measured in the conscious dog. 2. The changes in heart rate and stroke volume could be described by y = ym ‐ (ym‐yi)e‐kp, where yi and ym are initial and maximum values of the variable and p is the change in mean left atrial pressure. 3. Because cardiac output is a derived variable (stroke volume X heart rate) its response is described by a multiple exponential relationship. 4. For a given initial heart rate and inotropic state, the stroke volume response is determined by the Frank‐Starling mechanism and the pressure‐volume characteristics of the myocardium.