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Effects of prostaglandin antagonism on sodium arachidonate fever in rabbits.
Author(s) -
Laburn H,
Mitchell D,
Rosendorff C
Publication year - 1977
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1977.sp011826
Subject(s) - prostaglandin , arachidonic acid , chemistry , antagonism , pharmacology , hyperthermia , sodium , prostaglandin e2 , medicine , biochemistry , receptor , organic chemistry , enzyme
1. Sodium arachidonate, the prostaglandin precursor substance, when injected intraventricularly into rabbits, results in dose‐dependent hyperthermia, which is rapid in onset and of several hours duration. 2. Arachidonate fever was inhibited by intraventricular injection of indomethacin, but not by the simultaneous intraventricular injection of either of the two prostaglandin antagonists SC 19220 or HR 546. 3. Both antagonists effectively inhibited the fever induced by the intraventricular injection of an equipotent dose of PGE1. 4. Our results show that a derivative of arachidonic acid other than prostaglandin is pyrogenic.