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A study of the transport and permeability properties of the guinea‐pig amniotic membrane.
Author(s) -
North P M,
Segal M B
Publication year - 1976
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1976.sp011323
Subject(s) - amnion , sodium , permeability (electromagnetism) , gestation , amniotic fluid , epithelium , chemistry , andrology , fetus , endocrinology , gestational age , medicine , anatomy , biology , membrane , pregnancy , biochemistry , pathology , genetics , organic chemistry
1. The simultaneous measurement of the two‐way sodium flux across the in vitro amniotic epithelium did not reveal a preferential active movement of sodium in either direction. The amnion is thus unlikely to be the site of formation of amniotic fluid. 2. The permeability of the amniotic epithelium to some non‐electrolytes has been measured with isotopes and was found to be generally low in relation to the thinness of the tissue. The permeability to non‐electroytes would appear to be depebility to sodium and to non‐electrolytes was found to vary with gestational age. The amnion from animals of 61‐70 days' gestation was markedly more permanent than those at 50‐60 days (term 70 days).