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The study of (Methyl‐3H)decamethonium dichloride incorporation into normal and dystrophic mouse muscle.
Author(s) -
Marusyk H,
Monckton G
Publication year - 1976
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1976.sp011317
Subject(s) - decamethonium , diaphragm (acoustics) , denervation , anatomy , distribution (mathematics) , chemistry , medicine , endocrinology , acetylcholine , physics , acoustics , loudspeaker , mathematical analysis , mathematics
1. (Methyl‐3H)decamethonium dichloride was injected intravenously into the tail vein of dystrophic and normal mice of the Bar Harbour strain 129 ReJ/dy in paralysing doses. 2. Scintillation counts were made of 1 mm sections of diaphragm and tibialis anterior which showed a normal distribution of tritiated decamethonium in the dystrophic animals. 3. Intraperitoneal injections of L‐(gamma‐3H)leucine were made into dystrophic and normal mice. Examination of diaphragm and tibialis anterior by scintillation counting showed the abnormal uptake typical of dystrophic involvement of murine muscle. 4. The normal distribution of (methyl‐3H)decamethonium dichloride uptake by the dystrophic muscle does not support the concept of active denervation in this disease.