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The effect of 2‐deoxy‐D‐glucose and D‐glucose on the efferent discharge rate of sympathetic nerves.
Author(s) -
Niijima A
Publication year - 1975
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1975.sp011089
Subject(s) - efferent , efferent nerve , endocrinology , medicine , spinal cord , sensory nerve , chemistry , sensory system , afferent , biology , neuroscience , psychiatry
Efferent discharges were recorded from nerve filaments dissected from the adrenal and renal nerves in the rabbit. 2. An increase in discharge rate was observed in the adrenal nerve filaments following I.V. administration of 2‐deoxy‐D‐glucose (2‐DG). No change in discharge rate after 2‐DG infusion was observed in the renal nerve filaments. 3. A decrease in discharge rate of the adrenal nerve filaments was observed after I.V. injection of glucose, but there was no change in the activity of renal nerve filaments. 4. Transection of the spinal cord abolished the adrenal nerve response to the systemic administration of 2‐DG and glucose. 5. It is suggested that there might be a pathway from the hypothalmic area to the adrenal nerve cells of the spinal cord, but not to the renal nerve cells, through which activity of the adrenal nerve might be changed in response to 2‐DG and glucose infusion.