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The amplitude and the time course of the end‐plate current at various pH levels in the frog sartorius muscle.
Author(s) -
Scuka M
Publication year - 1975
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1975.sp011010
Subject(s) - amplitude , chemistry , sartorius muscle , biophysics , dissociation constant , time constant , dissociation (chemistry) , current (fluid) , analytical chemistry (journal) , thermodynamics , receptor , physics , biochemistry , chromatography , optics , biology , electrical engineering , engineering
1. The amplitude and the time course of the end‐plate current are dependent on the pH of the bathing solution. 2. When pH is changed from 5.4 to 9.4 the amplitude of the end‐plate current is increased and its decay is speeded up. 3. The change in the amplitude seems to be a result of a variation of quantal content. 4. The change in the time course of the end‐plate current is explained by assuming that the rate constants which determine the dissociation of the receptor‐mediator complex are affected by a change in pH. 5. This speculation is supported by the finding that the effect of membrane potential on amplitude and time course of the end‐plate current are dependent on pH of the bathing solution.