Premium
Descending inhibitory influences exerted by the brain stem upon the activities of dorsal horn lamina V cells induced by intra‐arterial injection of bradykinin into the limbs.
Author(s) -
Besson J M,
Guilbaud G,
Le Bars D
Publication year - 1975
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1975.sp010997
Subject(s) - excitatory postsynaptic potential , inhibitory postsynaptic potential , spinal cord , decerebrate state , nociception , bradykinin , cats , lumbar spinal cord , neuroscience , anesthesia , medicine , anatomy , chemistry , biology , receptor , stimulation , electric stimulation
1. In order to study descending influences of the brain stem upon the transmission of nociceptive messages at the spinal level, the activities of lumbar lamina V dorsal horn cells, induced by intra‐arterial injection of brandykinin into the limbs, were recorded in unanaesthetized cats in both decerebrate and temporary spinal states (reversible cold block applied at the thoracic level). 2. In the decerebrate state, the intra‐arterial injection of bradykinin had little or no effect. 3. During the reversible spinalization, the effects of bradykinin were revealed or considerably enhanced. As described in a previous study, in the C1‐transected cat, three types of effects were encountered: excitatory, inhibiitory and mixed (inhibitory‐excitatory). 4. These modifications observed after spinalization were generally associated with a large increase of the spontaneous firing rate. 5. These results emphasize, in the decerebrate cat, the importance of descending inhibitory controls exerted by the brain stem upon the transmission of nonciceptive messages at the spinal cord level.