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Preservation of early discharge of muscle afferents in acrylamide neuropathy.
Author(s) -
Sumner A J
Publication year - 1975
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1975.sp010890
Subject(s) - acrylamide , medicine , anatomy , chemistry , anesthesia , organic chemistry , copolymer , polymer
1. Responses to stretch and the ‘early discharge’ have been studied in acrylamide neuropathy in the expectation that functional block of the nerve terminals would allow these two processes to be dissociated. 2. Of 538 single group I and group II muscle afferents which were nonresponsive to stretch, ninety‐nine displayed ‘early discharge’ which appeared to be identical with that described in normally functioning muscle stretch afferents. 3. Preservation of ‘early discharge’ in non‐responsive fibres indicates these impulses do not arise from excitation of the muscle spindle itself. The evidence indicates that ‘early discharge’ is usually ephaptically excited by the muscle action potential.