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Regenerations of the noradrenergic innervation of the cardiovascular system of the chick following treatment with 6‐hydroxydopamine
Author(s) -
Bennett T.,
Malmfors T.
Publication year - 1974
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1974.sp010721
Subject(s) - hydroxydopamine , venae cavae , norepinephrine , medicine , endocrinology , anatomy , dopamine , dopaminergic
1. Fluorescence histochemical and pharmacological studies were made of the noradrenergic innervation of inferior venae cavae and left atria from 2‐ and 6‐week‐old chicks before, and following, treatment with 6‐hydroxydopamine. 2. Noradrenergic nerves in the younger animals appeared to be relatively resistant to the toxic effects of 6‐hydroxydopamine. 3. In the older animals, the time course of recovery from the effects of 6‐hydroxydopamine appeared to reflect the rate of regeneration of destroyed noradrenergic nerves. 4. Marked presynaptic supersensitivity to adrenaline and noradrenaline was observed in left atria and inferior venae cavae following treatment with 6‐hydroxydopamine.