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The effect of vasopressin upon the vasculature of the isolated perfused rat kidney
Author(s) -
Cross R. B.,
Trace J. W.,
Vattuone J. R.
Publication year - 1974
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1974.sp010576
Subject(s) - perfusion , vasopressin , arginine , medicine , kidney , endocrinology , chemistry , amino acid , biochemistry
The timed uptake of 131 I‐labelled human serum albumin was used as an index of regional perfusion in the isolated rat kidney. 1. Arginine vasopressin in doses of 1, 5 and 10 μu./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the 5 μu. dose. 2. Ornithine‐8‐vasopressin in doses of 5 and 10 μu./ml. of perfusate decreased papillary perfusion. Total renal perfusion was decreased only by the 10 μu. dose. 3. When the relative viscosity of the perfusate was increased to a value of 2·0 from the control value of 1·7, both papillary perfusion and total renal perfusion were reduced. 4. Arginine vasopressin further reduced papillary flow in kidneys perfused with high viscosity artificial plasma.