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Inhibition of thermoregulatory non‐shivering thermo‐genesis by trauma in cold‐acclimated rats
Author(s) -
Stoner H. B.
Publication year - 1974
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1974.sp010549
Subject(s) - brown adipose tissue , adipose tissue , shivering , blood flow , medicine , chemistry , endocrinology , thermogenesis , anatomy , anesthesia
1. Heat production and blood flow in the interscapular brown adipose tissue of 3° C acclimated rats have been measured by the heated thermo‐couple technique. 2. When the environmental temperature ( T a ) was reduced from 30 to 3° C heat production by the brown adipose tissue began to increase at the lower limit of the thermoneutral zone and then increased linearly. 3. Blood flow also increased when T a was reduced but was not so well correlated with T a . There was however a good positive correlation between blood flow and heat production. 4. During the first hour after a 4 hr period of bilateral hind‐limb ischaemia in a 20° C environment the percentage of rats not producing heat in the interscapular brown adipose tissue increased and the tissue blood flow fell. 5. By varying the T a of the injured rat it was found that the T a at which heat transfer from the interscapular brown adipose tissue commenced was significantly lower than in the controls although the slope of the regression lines relating heat production and T a was unaltered. 6. Blood flow also increased in the injured rat when T a was lowered but the increase in the tissue blood flow per unit increase in heat production was less than in the controls. 7. In a 5° C environment heat production in the interscapular brown adipose tissue of the injured rat was further increased by the S. C. injection of L ‐isoprenaline or L ‐noradrenaline. 8. It is concluded that the central control of thermoregulatory non‐shivering thermogenesis is inhibited after injury in the rat.