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The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs
Author(s) -
Katz B.,
Miledi R.
Publication year - 1973
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1973.sp010213
Subject(s) - decamethonium , depolarization , carbachol , acetylcholine , chemistry , acetylthiocholine , biophysics , membrane potential , medicine , biochemistry , biology , aché , receptor , acetylcholinesterase , enzyme
1. End‐plate depolarization and associated ‘membrane noise’ due to decamethonium, acetylthiocholine and suberyldicholine have been examined and compared with the effects of acetylcholine and carbachol. 2. The transient ionic channels resulting from the action of decamethonium and acetylthiocholine are of much shorter duration than those produced by acetylcholine. They are, therefore, similarly to carbachol channels, less effective in causing membrane depolarization. 3. Suberyldicholine, on the other hand, produces ion channels whose duration exceeds that of acetylcholine. 4. Lowering the temperature causes an increase in amplitude of the elementary potential change produced by decamethonium and acetylthiocholine. 5. The relation between the characteristic features of drug‐induced membrane noise and the underlying molecular reaction rates is discussed.