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Synaptic frequency response: the influence of sinusoidal changes in stimulation frequency on the amplitude of the end‐plate potential
Author(s) -
Landau E. M.,
Lass Y.
Publication year - 1973
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1973.sp010070
Subject(s) - stimulation , facilitation , neuroscience , comb filter , excitatory postsynaptic potential , filter (signal processing) , frequency response , amplitude , materials science , neuromuscular junction , physics , biophysics , acoustics , biology , computer science , optics , electrical engineering , inhibitory postsynaptic potential , engineering , computer vision
1. The synaptic response to frequency modulated trains of stimuli was investigated at the neuromuscular junction of the frog. The frequency of stimulation was usually varied sinusoidally about a carrier frequency of ca. 25 impulses per sec (Hz). 2. The post‐synaptic response to sinusoidally modulated trains of nerve stimuli was found to grow almost linearly when the variations in input frequency were increased up to 60% of the carrier frequency. 3. The synaptic frequency response (gain and phase) was reminiscent of that of a low‐pass filter, best transmitting slow variations in input frequency. 4. The synaptic filter characteristics could not be explained by the post‐synaptic cable properties, but were attributed to presynaptic facilitation processes.