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Functional relationship of longitudinal and circular layers of the muscularis externa of the rabbit large intestine
Author(s) -
McKirdy H. C.
Publication year - 1972
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1972.sp010061
Subject(s) - muscularis mucosae , rabbit (cipher) , circular muscle , anatomy , stimulation , smooth muscle , rhythm , chemistry , mechanism (biology) , tension (geology) , biophysics , biology , medicine , endocrinology , materials science , physics , mathematics , compression (physics) , statistics , quantum mechanics , composite material
1. The functional relationship of the longitudinal and circular layers of the muscularis externa of the rabbit large intestine has been studied in a flat preparation. 2. Evidence is presented that mechanical activity can be recorded independently and simultaneously from the two muscle layers of the flat preparation. Such evidence accrues mainly from results obtained from the flat preparation in response to various drugs. 3. During spontaneous rhythmic contractions and during the response to pelvic (parasympathetic) nerve stimulation, both layers show similar activity, never opposite or reciprocal activity. 4. In this flat preparation, the mechanism controlling the level of sustained tension (i.e. ‘tone’) may be dissociable, within limit, from the mechanism controlling rhythmic contractions.