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The effects of calcium and magnesium on statistical release parameters at the crayfish neuromuscular junction
Author(s) -
Wernig A.
Publication year - 1972
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1972.sp010008
Subject(s) - crayfish , neuromuscular junction , calcium , magnesium , excitatory postsynaptic potential , stimulus (psychology) , statistical analysis , extracellular , chemistry , biophysics , biology , neuroscience , fishery , mathematics , biochemistry , statistics , psychology , receptor , organic chemistry , psychotherapist
1. Transmitter release at excitatory neuromuscular junctions of crayfish muscle was studied at low temperature by recording synaptic potentials with extracellular micro‐electrodes. 2. Increasing the Ca concentration in the bathing solution produced an increase in the average number of quanta released per nerve stimulus ( m ). Increasing the Mg concentration resulted in a decrease in m . 3. Statistical analysis of fluctuations in the quantal release from trial to trial, assuming binomial statistics, indicated that both the changes in m were due to changes in the average quantal release probability ( p ).