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An attempt at an analysis of the factors determining the time course of the end‐plate current
Author(s) -
Kordaš M.,
Gabrovec I.,
Kordaš M.,
Popovič B.
Publication year - 1972
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1972.sp009897
Subject(s) - clamping , current (fluid) , phase (matter) , exponential function , mechanics , chemistry , mathematics , physics , engineering , mathematical analysis , thermodynamics , mechanical engineering , organic chemistry
1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end‐plate current. 2. The end‐plate current was measured by ‘clamping’ the membrane potential during neuromuscular transmission. 3. The falling phase of the end‐plate current was found to consist of a non‐exponential, and an exponential portion, the duration of both of which varies under different experimental conditions. 4. The results suggest that the rate constants determining the dissociation of the receptor—mediator complex seem greatly to influence the time course of the end‐plate current.