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The action of insulin on brown adipose tissue in vivo
Author(s) -
Hardman M. J.,
Hull D.
Publication year - 1972
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1972.sp009740
Subject(s) - adipose tissue , insulin , in vivo , action (physics) , brown adipose tissue , medicine , endocrinology , chemistry , biology , microbiology and biotechnology , physics , quantum mechanics
1. The action of insulin on the net exchange of glucose, free fatty acids and glycerol by brown adipose tissue of young rabbits was investigated. 2. Infusion of insulin (10,000 μu./kg.min I.V. for 10 min) caused a large increase in the uptake of glucose by brown adipose tissue of fed week‐old rabbits. The release of fatty acids fell but glycerol release was unchanged. 3. The brown adipose tissue of 9‐day‐old rabbits fasted in a warm environment had a high initial rate of fatty acid and glycerol release and low rates of glucose uptake. Insulin infusions (10,000 and 100 μu./kg.min) greatly reduced fatty acid release but had little or no effect on glucose uptake. 4. The brown adipose tissue of 9‐day‐old rabbits fasted in a cold environment was depleted of fat and took up free fatty acid as well as glucose from the circulation. Infusion of insulin (10,000 μu./kg.min) caused a large increase in glucose uptake accompanied by a reduction in fatty acid uptake. 5. The experiments support the view that insulin has a direct effect on fatty acid transport across the cell membrane.