Premium
Further studies on prostaglandin E 1 fever in cats
Author(s) -
Feldberg W.,
Saxena P. N.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009686
Subject(s) - cats , hyperthermia , hypothalamus , anterior hypothalamus , rectal temperature , prostaglandin , prostaglandin e , anesthesia , chemistry , prostaglandin e2 , cerebral ventricle , endocrinology , medicine
1. Micro‐injections of a few nanograms of prostaglandin E 1 (PGE 1 ) into the anterior hypothalamus of unanaesthetized cats produced a rise in rectal temperature, whereas temperature was not affected when micro‐injections of even larger doses were made into the posterior hypothalamus. The hyperthermia produced by injections of PGE 1 into the cerebral ventricles is therefore attributed to an action of PGE 1 on the anterior hypothalamus. 2. During a pentobarbitone sodium anaesthesia the sensitivity of cats to the hyperthermic effect of PGE 1 injected into the cerebral ventricles was found to be greatly reduced, particularly during the early stage of anaesthesia when body temperature was falling steeply.