Premium
Effect of microcirculation changes on brain tissue oxygenation
Author(s) -
Bicher H. I.,
Bruley D.,
Knisely M. H.,
Reneau D. D.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009594
Subject(s) - oxygenation , cats , microcirculation , anesthesia , chemistry , oxygen , dextran , brain tissue , medicine , chromatography , organic chemistry
1. A new, 2 μ tip, oxygen micro‐electrode and a constantly circulated Beckman oxygen gas analyser were used to measure tissue and blood P O 2 in anaesthetized, curarized cats under positive pressure breathing. As a parameter for the ability of the circulation to oxygenate tissue, the ‘reoxygenation time’ (defined as the time required to reach the previous P O 2 level after a short period of anoxic anoxia) was determined on blood and cerebral cortex. 2. First, it was found that haemorrhage (from 15–25 c.c./kg) alone or haemorrhage combined with sludging of the blood (by the I.V. administration of high molecular weight Dextran, 1 g/kg) markedly diminished P O 2 levels in blood and tissue. 3. Further, the reoxygenation time was significantly affected by these procedures. Sludging markedly prolonged the reoxygenation time, an effect counteracted by the use of an anti‐adhesive drug breaking up the red cell aggregates. 4. Bleeding prolonged the reoxygenation time up to four times that found in the same animals previous to the bleeding.