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The mechanism of thyroxine transfer from plasma to tissue binding sites
Author(s) -
Hillier A. P.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009590
Subject(s) - chemistry , thyroxine binding globulin , endocrinology , medicine , globulin , thyroxine binding proteins , albumin , dissociation (chemistry) , binding site , triiodothyronine , biochemistry , hormone , biology
1. An examination has been made of the uptake of thyroxine by rat livers perfused with very dilute solutions of thyroxine‐binding globulin (TBG) and thyroxine‐binding pre‐albumin (TBPA). 2. Under these circumstances the rate of transfer of thyroxine to the liver is very similar to the rate of thyroxine dissociation for both TBG and TBPA. 3. It is concluded that thyroxine transfer from plasma to tissue‐binding sites involves its initial release into the free state and not, as has been suggested, directed exchange.