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Site of adrenaline blockade in the superior cervical ganglion of the rabbit
Author(s) -
Christ D. D.,
Nishi S.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009371
Subject(s) - rabbit (cipher) , superior cervical ganglion , blockade , ganglion , chemistry , anesthesia , medicine , anatomy , receptor , computer science , computer security
1. The blocking action of adrenaline on the superior cervical ganglion of the rabbit was investigated with intracellular recording techniques. 2. Adrenaline (10 −5 M ) blocked initiation of post‐synaptic action potentials and decreased the amplitude of excitatory post‐synaptic potentials (e.p.s.p.s), but did not hyperpolarize the post‐synaptic membrane. 3. The depressant action of adrenaline was antagonized by phenoxy‐benzamine and dihydroergotamine. 4. Acetylcholine depolarizations from iontophoretic ACh were not affected by adrenaline. 5. Adrenaline decreased the frequency of miniature excitatory post‐synaptic potentials (m.e.p.s.p.s) and decreased the quantal content of e.p.s.p.s in a low [Ca 2+ ]: [Mg 2+ ] media. 6. It was concluded that adrenaline blocks ganglionic transmission by acting at an alpha‐adrenoceptive site in the presynaptic nerve terminals.