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The effect of light chloralose and pentobarbitone anaesthesia on the acid—base state and oxygenation of arterial blood in dogs
Author(s) -
Ledsome J. R.,
Linden R. J.,
Norman J.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009345
Subject(s) - chloralose , anesthesia , oxygenation , arterial blood , acid–base homeostasis , chemistry , respiratory system , oxygen , oxygen tension , medicine , blood pressure , biochemistry , organic chemistry
1. The effects of light anaesthesia of approximately 8 hr duration using either pentobarbitone or chloralose on the acid—base balance and oxygenation of arterial blood were determined in dogs breathing spontaneously. 2. With pentobarbitone anaesthesia there was a slight initial respiratory acidaemia. 3. With chloralose there was a non‐respiratory acidaemia which was probably the result of using an unbuffered solvent. 4. Changes in the acid—base balance and the oxygen concentration of the arterial blood over the course of each experiment were minimal. 5. In one animal a pH of 7·07 was recorded; in others the oxygen tension on occasion was between 50 and 60 mm Hg. The value of monitoring the acid—base state and the oxygenation of blood in experimental preparations is discussed.