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An examination of the extent of reversibility of thyroxine binding within the thyroxine distribution space in the rabbit
Author(s) -
Nathanielsz P. W.
Publication year - 1971
Publication title -
the journal of physiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.802
H-Index - 240
eISSN - 1469-7793
pISSN - 0022-3751
DOI - 10.1113/jphysiol.1971.sp009334
Subject(s) - endocrinology , distribution (mathematics) , rabbit (cipher) , medicine , chemistry , space (punctuation) , biology , mathematics , statistics , computer science , mathematical analysis , operating system
1. New Zealand white rabbits were injected intraperitoneally with [ 125 ] L ‐thyroxine. Experiments were performed after 24 hr had elapsed. 2. Thyroxine distribution space was calculated as 129 ml. kg −1 . Half‐life of disappearance of thyroxine from the blood of the urethane anaesthetized rabbit was 653 min. 3. After exchange of approximately 20 ml. kg −1 whole blood with heparinized blood from a non‐radioactive donor, equilibration of radioactivity in the recipient had produced a peak radioactivity by 2 hr. 4. The thyroxine space in which complete exchange took place within 2 hr was 102·7 ± 4·7 ml. kg −1 in six rabbits. This is 79·6% of the thyroxine distribution space. 5. These results are compared with observations in the rat.